PA3-228 detects Atrial Natriuretic Peptide in rat samples. PA3-228 is expected to react with human samples due to sequence homology.
PA3-228 has successfully been used in WB and mmunocytochemical procedures.
The PA3-228 immunogen is a synthetic cyclized peptide corresponding to ANP.
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.
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Protein Aliases: ANF; ANP; ATFB6; Atrial natriuretic factor; Atrial natriuretic peptide; Atriopeptin I; Atriopeptin II; Atriopeptin III; Atriopeptin-1; Atriopeptin-2; Atriopeptin-3; Auriculin-A; Auriculin-B; Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); natriuretic peptide precursor type A; Natriuretic peptides A; NPPA; PND; Prepronatriodilatin
Gene Aliases: ANF; ANP; Nppa; Pnd; RATANF
UniProt ID: (Rat) P01161
Entrez Gene ID: (Rat) 24602