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Invitrogen
AP2 beta Polyclonal Antibody
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Product Details
PA5-17348
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the sequence of human AP-2β
Conjugate
Form
Liquid
Concentration
137 µg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activating enhancer binding protein 2 beta; Activating enhancer-binding protein 2-beta; AP-2 beta; AP2-beta; Transcription factor AP-2-beta; unnamed protein product
Gene Aliases: AP-2B; AP-2beta; AP2-B; PDA2; TFAP2B
UniProt ID: (Human) Q92481
Entrez Gene ID: (Human) 7021
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
protein heterodimerization activity
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
kidney development
glucose metabolic process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nervous system development
sensory organ development
positive regulation of cell proliferation
negative regulation of cell proliferation
response to xenobiotic stimulus
gene expression
retina layer formation
regulation of BMP signaling pathway
forelimb morphogenesis
hindlimb morphogenesis
aorta morphogenesis
regulation of cell proliferation
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
skin development
fat cell differentiation
regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
smooth muscle tissue development
regulation of insulin secretion
neuron apoptotic process
distal tubule development
collecting duct development
metanephric nephron development
ductus arteriosus closure
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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