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Bioss
APBA2 Polyclonal Antibody
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Product Details
BS-11651R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human APBA2, amino acids 351-450.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein X11beta; amyloid beta (A4) precursor protein-binding family A member 2 (X11-like); amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); amyloid beta A4 precursor protein-binding family A member 2; Amyloid-beta A4 precursor protein-binding family A member 2; Mint 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11-like protein
Gene Aliases: APBA2; D15S1518E; HsT16821; LIN-10; MGC:14091; MINT2; mXllL; X11-BETA; X11-like; X11L; XllL
UniProt ID: (Human) Q99767, (Rat) O35431, (Mouse) P98084
Entrez Gene ID: (Human) 321, (Rat) 83610, (Mouse) 11784
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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