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FIGURE: 1 / 1
APBA3/Mint3/X11gamma Antibody (BS-11058R) in WB
Lane 1: mouse spleen lysates Lane 2: mouse brain lysates probed with Anti APBA3/Mint3/X11 gamma Polyclonal Antibody, Unconjugated (bs-11058R) at 1:200 in 4°C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90 min in 37°C. Predicted band 63 kD. Observed band size: 63 kD.
Product Details
BS-11058R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from rat Mint3, amino acids 241-340.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The munc-18 interacting protein (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three mint isoforms, Mint1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint1 and 2 appear to be expressed exclusively in the brain and are found to bind to Munc18, an essential component of the synaptic vesicle fusion machinery. Mint3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that mint3 does not interact with munc-18. Mint3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that mint3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein X11gamma; amyloid beta (A4) precursor protein-binding family A member 3 (X11-like 2); amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2); amyloid beta A4 precursor protein-binding family A member 3; Amyloid-beta A4 precursor protein-binding family A member 3; lin 10; Mint 3; Mint-3; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3
Gene Aliases: Apba3; AW208791; lin-10; Mint-3; Mint3; X11gamma
UniProt ID: (Rat) O70248, (Mouse) O88888
Entrez Gene ID: (Rat) 83611, (Mouse) 57267
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