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Product Details
H00000325-M11
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4F3
Immunogen
APCS (AAH07058.1, 35 a.a. approximately 149 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: VTDHVNLITP LEKPLQNFTL CFRAYSDLSR AYSLFSYNTQ GRDNELLVYK ERVGEYSLYI GRHKVTSKVI EKFPAPVHIC VSWESSSGIA EFWINGTPLV KKGLRQGYFV EAQPK
Target Information
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 9.5S alpha-1-glycoprotein; epididymis secretory sperm binding protein Li 92n; MGC88159; Pentaxin related; pentaxin-related; Pentraxin 2; pentraxin-2; pentraxin-related; PTX 2; SAMP; SAP; Serum amyloid P-component
Gene Aliases: APCS; HEL-S-92n; PTX2; SAP
UniProt ID: (Human) P02743
Entrez Gene ID: (Human) 325
negative regulation of acute inflammatory response
protein folding
acute-phase response
cellular protein metabolic process
negative regulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral glycoprotein metabolic process
innate immune response
negative regulation of monocyte differentiation
negative regulation of viral entry into host cell
negative regulation of viral process
chaperone-mediated protein complex assembly
negative regulation of wound healing
negative regulation of exo-alpha-sialidase activity
negative regulation of glycoprotein metabolic process
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