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Proteintech
APJ Polyclonal Antibody
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Product Details
20341-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APJ Fusion Protein Ag14138 (301-380 aa encoded by BC032688)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NSCLNPFLY AFFDPRFRQA CTSMLCCGQS RCAGTSHSSS GEKSASYSSG HSQGPGPNMG KGGEQMHEKS IPYSQETLVV D (301-380 aa encoded by BC032688)
Target Information
APLNR (Apelin Receptor) is a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: angiotensin II receptor-like 1; Angiotensin receptor-like 1; Apelin receptor; APJ (apelin) receptor; APJ receptor; G protein-coupled receptor APJ; G-protein coupled receptor APJ; G-protein coupled receptor HG11; HG11 orphan receptor; MSR; unnamed protein product
Gene Aliases: AGTRL1; APJ; APJR; APLNR; HG11; msr/apj
UniProt ID: (Human) P35414, (Mouse) Q9WV08
Entrez Gene ID: (Human) 187, (Mouse) 23796
angiogenesis
blood vessel development
vasculogenesis
vasculature development
heart looping
G-protein coupled receptor internalization
atrioventricular valve development
endocardial cushion formation
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
gastrulation
heart development
adult heart development
regulation of gene expression
positive regulation of cardiac muscle hypertrophy
negative regulation of gene expression
vascular smooth muscle cell differentiation
aorta development
negative regulation of cAMP-mediated signaling
positive regulation of angiogenesis
regulation of body fluid levels
positive regulation of release of sequestered calcium ion into cytosol
apelin receptor signaling pathway
ventricular septum morphogenesis
venous blood vessel development
coronary vasculature development
negative regulation of cardiac muscle hypertrophy in response to stress
positive regulation of cardiac muscle hypertrophy in response to stress
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
regulation of gap junction assembly
positive regulation of G protein-coupled receptor internalization
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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