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Proteintech
APLP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
12305-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APLP1 Fusion Protein Ag2951 (55-341 aa encoded by BC012889)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QVAGLCGRL TLHRDLRTGR WEPDPQRSRR CLRDPQRVLE YCRQMYPELQ IARVEQATQA IPMERWCGGS RSGSCAHPHH QVVPFRCLPG EFVSEALLVP EGCRFLHQER MDQCESSTRR HQEAQEACSS QGLILHGSGM LLPCGSDRFR GVEYVCCPPP GTPDPSGTAV GDPSTRSWPP GSRVEGAEDE EEEESFPQPV DDYFVEPPQA EEEEETVPPP SSHTLAVVGK VTPTPRPTDG VDIYFGMPGE ISEHEGFLRA KMDLEERRMR QINEVMREWA MADNQSKN (55-341 aa encoded by BC012889 )
Target Information
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Amyloid beta (A4) precursor-like protein 1; Amyloid beta precursor like protein 1; amyloid precursor-like protein 1; Amyloid-like protein 1; APLP; APLP 1; APLP-1; APLPAPLP-1; unnamed protein product
Gene Aliases: APLP; APLP1
UniProt ID: (Mouse) Q03157
Entrez Gene ID: (Human) 333, (Mouse) 11803
nervous system development
axonogenesis
central nervous system development
organ morphogenesis
extracellular matrix organization
forebrain development
animal organ development
cellular response to norepinephrine stimulus
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
mRNA polyadenylation
regulation of translation
endocytosis
apoptotic process
cell adhesion
negative regulation of cAMP biosynthetic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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