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Product Details
PA5-109399
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 285-490 of human APLP1 (NP_0051571)
Conjugate
Form
Liquid
Concentration
1.09 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854810
Product Specific Information
Immunogen sequence: TPTPRPTDGV DIYFGMPGEI SEHEGFLRAK MDLEERRMRQ INEVMREWAM ADNQSKNLPK ADRQALNEHF QSILQTLEEQ VSGERQRLVE THATRVIALI NDQRRAALEG FLAALQADPP QAERVLLALR RYLRAEQKEQ RHTLRHYQHV AAVDPEKAQQ MRFQVHTHLQ VIEERVNQSL GLLDQNPHLA QELRPQIQEL LHSEHL
Target Information
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amyloid beta (A4) precursor-like protein 1; Amyloid beta precursor like protein 1; amyloid precursor-like protein 1; Amyloid-like protein 1; APLP; APLP 1; APLP-1; APLPAPLP-1
Gene Aliases: APLP; APLP1; Aplp1_retired; RGD1561211
UniProt ID: (Human) P51693, (Mouse) Q03157
Entrez Gene ID: (Human) 333, (Rat) 502317, (Mouse) 11803
endocytosis
apoptotic process
cell adhesion
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
nervous system development
organ morphogenesis
negative regulation of cAMP biosynthetic process
cellular response to norepinephrine stimulus
mRNA polyadenylation
regulation of translation
extracellular matrix organization
forebrain development
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