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Invitrogen
APLP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-120825
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 470-580 of human APLP1 (NP_0051571)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.99 mg/mL
Amount
99 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: C6, Mouse brain, Rat brain. The target is usually found in the following locations: Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Immunogen sequence: NPHLAQELRP QIQELLHSEH LGPSELEAPA PGGSSEDKGG LQPPDSKDDT PMTLPKGSTE QDAASPEKEK MNPLEQYERK VNASVPRGFP FHSSEIQRDE LAPAGTGVSR E
Target Information
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amyloid beta (A4) precursor-like protein 1; amyloid precursor-like protein 1; amyloid-like protein 1; APLP; APLP 1; APLP-1; APLPAPLP-1; unnamed protein product
Gene Aliases: APLP; Aplp1_retired; RGD1561211
UniProt ID: (Human) P51693, (Mouse) Q03157
Entrez Gene ID: (Human) 333, (Mouse) 11803, (Rat) 502317
regulation of translation
nervous system development
axonogenesis
central nervous system development
extracellular matrix organization
forebrain development
animal organ development
cellular response to norepinephrine stimulus
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
cytosolic mRNA polyadenylation
organ morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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