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Product Details
H00000336-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4F3
Immunogen
APOA2 (AAH05282, 1 a.a. approximately 100 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
Sequence of this protein is as follows: MKLLAATVLL LTICSLEGAL VRRQAKEPCV ESLVSQYFQT VTDYGKDLME KVKSPELQAE AKSYFEKSKE QLTPLIKKAG TELVNFLSYF VELGTQPATQ
Target Information
At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL, and VLDL particles of human serum are often used to estimate an individual's relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins ( especially A-1 and B) have been suggested to be more accurate estimators of coronary heart disease that measurements of lipoprotein particles (especially HDL and LDL). The apolipoproteins are derived from human plasma by density gradient ultracentrifugation and HPLC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APO A2; Apo-AII; Apolipoprotein; Apolipoprotein A-II; Apolipoprotein A-II(1-76); Apolipoprotein A2; Apolipoprotein AII; ProapoA-II; Proapolipoprotein A-II; Truncated apolipoprotein A-II
Gene Aliases: Apo-AII; ApoA-II; APOA2; apoAII
UniProt ID: (Human) P02652
Entrez Gene ID: (Human) 336
Molecular Function:
apolipoprotein
retinoid metabolic process
acute inflammatory response
negative regulation of cytokine secretion involved in immune response
triglyceride metabolic process
phosphatidylcholine biosynthetic process
cholesterol metabolic process
phospholipid catabolic process
response to glucose
positive regulation of cholesterol esterification
negative regulation of very-low-density lipoprotein particle remodeling
viral process
protein oxidation
peptidyl-methionine modification
regulation of intestinal cholesterol absorption
organ regeneration
regulation of protein stability
negative regulation of cholesterol transport
cholesterol efflux
phospholipid efflux
triglyceride-rich lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
lipoprotein metabolic process
lipoprotein biosynthetic process
response to drug
cholesterol homeostasis
positive regulation of catalytic activity
response to estrogen
reverse cholesterol transport
positive regulation of interleukin-8 biosynthetic process
diacylglycerol catabolic process
negative regulation of lipid catabolic process
positive regulation of lipid catabolic process
response to glucocorticoid
negative regulation of lipase activity
negative regulation of cholesterol import
negative regulation of cholesterol transporter activity
lipid transporter activity
protein binding
phospholipid binding
high-density lipoprotein particle binding
lipid binding
cholesterol binding
cholesterol transporter activity
phosphatidylcholine binding
apolipoprotein receptor binding
protein homodimerization activity
protein heterodimerization activity
lipase inhibitor activity
phosphatidylcholine-sterol O-acyltransferase activator activity
high-density lipoprotein particle receptor binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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