Invitrogen

APOBEC1 Polyclonal Antibody

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APOBEC1 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of formalin-fixed, paraffin-embedded human cancer tissue using an Apobec1 polyclonal antibody (Product # PA5-11429), followed by HRP-conjugated secondary antibody and DAB staining.

APOBEC1 Antibody in Western Blot (WB) — Western blot analysis of Apobec1 using an Apobec1 polyclonal antibody (Product # PA5-11429) in mouse small intestine tissue lysate.

Product Details

Tested Applications

Dilution

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

Western Blot (WB)

1:1000

Product Specifications

Species Reactivity

Human, Mouse

Host / Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human Apobec1

Conjugate

Unconjugated

Form

Liquid

Concentration

2.0 mg/mL

Purification

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2258411

Target Information

APOBEC1 is involved in the production of apolipoprotein B (apoB)-48 from apoB-100. The gene spans 18 kb and contains five exons, all of which are translated. Alternative splicing produces a variant transcript that lacks exon 2 and encodes a novel 36-amino acid peptide. The exon 2-skipped transcript accounts for approximately 50% of APOBEC1 mRNA in the adult small intestine and up to 90% of APOBEC1 mRNA in the developing gut. Exon 2-skipping may thus be a quantitatively important mechanism for regulating the expression of this gene in the gastrointestinal tract.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: apolipoprotein B editing complex 1; apolipoprotein B mRNA editing enzyme catalytic polypeptide 1; apolipoprotein B mRNA editing enzyme complex-1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; Apolipoprotein B mRNA-editing enzyme 1; C->U-editing enzyme APOBEC-1; HEPR; mRNA(cytosine(6666)) deaminase 1

Gene Aliases: APOBEC-1; APOBEC1; BEDP; CDAR1; HEPR

UniProt ID: (Human) P41238, (Mouse) P51908

Entrez Gene ID: (Human) 339, (Mouse) 11810

Molecular Function: deaminase hydrolase nucleic acid binding