APOBEC1 is involved in the production of apolipoprotein B (apoB)-48 from apoB-100. The gene spans 18 kb and contains five exons, all of which are translated. Alternative splicing produces a variant transcript that lacks exon 2 and encodes a novel 36-amino acid peptide. The exon 2-skipped transcript accounts for approximately 50% of APOBEC1 mRNA in the adult small intestine and up to 90% of APOBEC1 mRNA in the developing gut. Exon 2-skipping may thus be a quantitatively important mechanism for regulating the expression of this gene in the gastrointestinal tract.
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Protein Aliases: apolipoprotein B editing complex 1; apolipoprotein B mRNA editing enzyme catalytic polypeptide 1; apolipoprotein B mRNA editing enzyme complex-1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; Apolipoprotein B mRNA-editing enzyme 1; C->U-editing enzyme APOBEC-1; HEPR; mRNA(cytosine(6666)) deaminase 1
Gene Aliases: APOBEC-1; APOBEC1; BEDP; CDAR1; HEPR