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Invitrogen
APOBEC1 Polyclonal Antibody
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APOBEC1 Antibody (PA5-11429) in IHC (P)
Immunohistochemistry analysis of APOBEC1 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with APOBEC1 polyclonal antibody (Product # PA5-11429) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = ... View More
Product Details
PA5-11429
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human Apobec1
Conjugate
Form
Liquid
Concentration
2.0 mg/mL
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor and APOBEC1 stimulating protein . This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: APO1; APOBEC-1; apolipoprotein B editing complex 1; apolipoprotein B mRNA editing enzyme catalytic polypeptide 1; apolipoprotein B mRNA editing enzyme complex-1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; apolipoprotein B mRNA-editing enzyme 1; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1; Apolipoprotein B mRNA-editing enzyme catalytic subunit 1; C->U-editing enzyme APOBEC-1; HEPR; mRNA(cytosine(6666)) deaminase 1
Gene Aliases: APOBEC-1; APOBEC1; BEDP; CDAR1; HEPR
UniProt ID: (Human) P41238, (Mouse) P51908
Entrez Gene ID: (Human) 339, (Mouse) 11810
RNA binding
mRNA binding
cytidine deaminase activity
cytosine deaminase activity
protein binding
enzyme activator activity
zinc ion binding
AU-rich element binding
protein domain specific binding
ribonucleoprotein complex binding
catalytic activity
GTP cyclohydrolase activity
tRNA-specific adenosine deaminase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
N-cyclopropylmelamine deaminase activity
N-cyclopropylammeline deaminase activity
N-cyclopropylammelide alkylamino hydrolase activity
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity
tRNA-specific adenosine-37 deaminase activity
archaeal-specific GTP cyclohydrolase activity
metal ion binding
tRNA-specific adenosine-34 deaminase activity
RNA processing factor
RNA processing
mRNA processing
lipid metabolic process
response to osmotic stress
cytidine deamination
response to zinc ion
response to gamma radiation
cytidine to uridine editing
mRNA modification
cellular response to insulin stimulus
regulation of cell proliferation
lipoprotein biosynthetic process
response to drug
lipoprotein transport
positive regulation of catalytic activity
response to ethanol
mRNA stabilization
response to calcium ion
defense response to virus
DNA cytosine deamination
DNA demethylation
negative regulation of methylation-dependent chromatin silencing
positive regulation of mRNA modification
lipoprotein metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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