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Invitrogen
APOBEC3A Polyclonal Antibody
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FIGURE: 1 / 6
APOBEC3A Antibody (PA5-99584) in IHC (P)
Immunohistochemistry analysis of APOBEC3A in human pancreatic cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with APOBEC3A polyclonal antibody (Product # PA5-99584) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-99584
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human APOBEC3A(Accession P31941), corresponding to amino acid residues I26-L76.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The immunogen sequence for PA5-99584 is VKMDQHRGFLHN.
Antibody detects endogenous levels of total APOBEC3A.
Target Information
PHO1 a member of the cytidine deaminase gene family. The PHO1 gene is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. This gene encodes a protein that lacks the zinc binding activity and may be an expressed pseudogene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A3A; apolipoprotein B editing complex 3; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; Apolipoprotein B mRNA-editing complex 3; Arp3; bK150C2.1; CEM-15; CEM15; DNA dC->dU-editing enzyme APOBEC-3; DNA dC->dU-editing enzyme APOBEC-3A; PHO-1; pho1; Phorbolin-1; Phorbolin1; probable DNA dC->dU-editing enzyme APOBEC-3A; recovery from Friend virus 3
Gene Aliases: A3A; Apobec3; APOBEC3A; ARP3; BC003314; bK150C2.1; Cem15; PHRBN; Rfv3
UniProt ID: (Human) P31941, (Mouse) Q99J72
Entrez Gene ID: (Human) 200315, (Mouse) 80287
RNA binding
catalytic activity
cytidine deaminase activity
protein binding
zinc ion binding
hydrolase activity
metal ion binding
GTP cyclohydrolase activity
tRNA-specific adenosine deaminase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
N-cyclopropylmelamine deaminase activity
N-cyclopropylammeline deaminase activity
N-cyclopropylammelide alkylamino hydrolase activity
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity
tRNA-specific adenosine-37 deaminase activity
archaeal-specific GTP cyclohydrolase activity
poly(A) RNA binding
deoxycytidine deaminase activity
tRNA-specific adenosine-34 deaminase activity
RNA processing factor
immune system process
negative regulation of transposition, RNA-mediated
cytidine to uridine editing
hypomethylation of CpG island
clearance of foreign intracellular DNA
negative regulation of viral genome replication
innate immune response
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
defense response to virus
DNA cytosine deamination
hematopoietic progenitor cell differentiation
metabolic process
negative regulation of transposition
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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