Keep as concentrated solution.
Positive Control: A431, Jurkat, Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5-a which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A3G; APOBEC-related cytidine deaminase; APOBEC-related cytidine deaminase antibody; APOBEC-related protein; APOBEC-related protein 9; APOBEC-related protein 9 antibody; APOBEC3G antibody; apolipoprotein B editing enzyme catalytic polypeptide-like 3G; apolipoprotein B mRNA editing enzyme; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B mRNA editing enzyme cytidine deaminase antibody; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G; ARCD antibody; ARP-9; ARP-9 antibody; ARP9 antibody; bK150C2.7 antibody; catalytic polypeptide-like 3G antibody; CEM-15; CEM-15 antibody; CEM15; CEM15 antibody; Deoxycytidine deaminase; dJ494G10.1 antibody; DNA dC->dU editing enzyme; DNA dC->dU editing enzyme antibody; DNA dC->dU-editing enzyme APOBEC-3G; DNA dC->dU-editing enzyme APOBEC-3G antibody; FLJ12740 antibody; phorbolin-like protein MDS019; phorbolin-like protein MDS019 antibody
Gene Aliases: A3G; APOBEC3G; ARCD; ARP-9; ARP9; bK150C2.7; CEM-15; CEM15; dJ494G10.1; MDS019
UniProt ID: (Human) Q9HC16
Entrez Gene ID: (Human) 60489