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Invitrogen
APOC2 Polyclonal Antibody
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FIGURE: 1 / 4
APOC2 Antibody (PA5-102480) in IHC (P)
Immunohistochemistry analysis of APOC2 in mouse liver tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with APOC2 polyclonal antibody (Product # PA5-102480) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102480
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human APOC2(Accession P02655), corresponding to amino acid residues G2-K52.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total APOC2.
Target Information
Apolipoproteins are protein components of plasma lipoproteins. The apolipoprotein C gene family encodes four homologous proteins designated apoC-I to -IV, which specifically modulate the metabolism of triglyceride-rich lipoproteins. The human apoC-I gene maps to chromosome 19q13.2 and is expressed primarily in the liver where it is activated when monocytes differentiate into macrophages. The human apoC-II gene maps to chromosome 19q13.2 and encodes a 79 amino acid single chain protein that is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: APC 2; APO C2; Apo CII; Apo-CII; APOC 2; ApoC II; apoC-II; APOC2 protein; ApoCII; Apolipoprotein C II; Apolipoprotein C-II; Apolipoprotein C2; Apolipoprotein CII; ApolipoproteinCII; MGC75082
Gene Aliases: APC2; APO-CII; APOC-II; APOC2; RGD1560725
UniProt ID: (Human) P02655, (Mouse) Q05020, (Rat) G3V8D4
Entrez Gene ID: (Human) 344, (Mouse) 11813, (Rat) 292697
protein binding
enzyme activator activity
lipid binding
phospholipase activator activity
identical protein binding
phospholipase binding
lipase inhibitor activity
lipoprotein lipase activator activity
molecular function activator activity
protein homodimerization activity
molecular_function
apolipoprotein
lipid metabolic process
lipid transport
positive regulation of triglyceride catabolic process
positive regulation of very-low-density lipoprotein particle remodeling
negative regulation of very-low-density lipoprotein particle clearance
lipid catabolic process
negative regulation of cholesterol transport
cholesterol efflux
phospholipid efflux
triglyceride-rich lipoprotein particle remodeling
chylomicron remodeling
very-low-density lipoprotein particle remodeling
chylomicron remnant clearance
high-density lipoprotein particle clearance
lipoprotein catabolic process
cholesterol homeostasis
reverse cholesterol transport
positive regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
positive regulation of phospholipid catabolic process
triglyceride homeostasis
transport
positive regulation of phospholipase activity
lipoprotein transport
negative regulation of catalytic activity
positive regulation of lipoprotein lipase activity
response to drug
positive regulation of catalytic activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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