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      APOE Polyclonal Antibody

      See 11 other APOE antibodies ›
      APOE Polyclonal Antibody for Western Blot and IHC

      Catalog#: PA5-18361 Invitrogen

      Catalog # Size Price (USD) Qty Datasheet
      PA5-18361 100 ug
      349.00
      Please enter a quantity in the range of 1 to 199.
      Suggested Secondary Antibodies

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      Product Details

      Bioinformatics

      Documents
      Details
      Tested species reactivity Human
      Host / Isotype Goat / IgG
      Class Polyclonal
      Type Antibody
      Immunogen Synthetic peptide sequence (VGTSAAPVPSDNH) corresponding to the C-terminus amino acids of APOE
      Conjugate Unconjugated
      Form Liquid
      Concentration 0.5 mg/ml
      Purification Antigen affinity chromatography
      Storage buffer TBS, pH 7.3, with 0.5% BSA
      Contains 0.02% sodium azide
      Storage Conditions -20° C, Avoid Freeze/Thaw Cycles
      Tested Applications Dilution *
      Immunohistochemistry (IHC) 2-4µg/ml
      Western Blot (WB) 0.1-0.3 ug/ml

      * Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

      Background/Target Information

      Chylomicron remnants and very low density lipoprotein remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia , in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      Bioinformatics

      Protein Aliases:

      AD2; Alzheimer disease 2 (APOE*E4-associated, late onset); Apo-E; APOE; Apolipoprotein E; apolipoprotein E3; apoprotein; LPG; MGC1571

      Gene Aliases:

      AD2; APO-E; APOE; LDLCQ5; LPG

      UniProt ID:

      (Human) P02649

      Entrez Gene ID:

      (Human) 348

      Function(s) Process(es)

      Documents

      Material safety data sheets (MSDS)

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