Search
Proteintech
APPL2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
14294-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APPL2 Fusion Protein Ag5626 (314-664 aa encoded by BC033731)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RGAVAGGLI QDLDNCSVMA VDCEDRRYCF QITTPNGKSG IILQAESRKE NEEWICAINN ISRQIYLTDN PEAVAIKLNQ TALQAVTPIT SFGKKQESSC PSQNLKNSEM ENENDKIVPK VTASLPEAEE LIAPGTPIQF DIVLPATEFL DQNRGSRRTN PFGETEDESF PEAEDSLLQQ MFIVRFLGSM AVKTDSTTEV IYEAMRQVLA ARAIHNIFRM TESHLMVTSQ SLRLIDPQTQ VSRANFELTS VTQFAAHQEN KRLVGFVIRV PESTGEESLS TYIFESNSEG EKICYAINLG KEIIEVQKDP EALAQLMLSI PLTNDGKYVL LNDQPDDDDG NPNEHRGAES EA (314-664 aa encoded by BC033731)
Target Information
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13 beta; Dip13-beta; Dip3 beta; unnamed protein product
Gene Aliases: APPL2; DIP13B; Dip3b; RGD1563028
UniProt ID: (Human) Q8NEU8, (Rat) B4F779, (Mouse) Q8K3G9
Entrez Gene ID: (Human) 55198, (Rat) 362860, (Mouse) 216190
diet induced thermogenesis
protein import into nucleus
signal transduction
transforming growth factor beta receptor signaling pathway
cold acclimation
regulation of fibroblast migration
signaling
adiponectin-activated signaling pathway
regulation of toll-like receptor 4 signaling pathway
cellular response to hepatocyte growth factor stimulus
homeostatic process
glucose homeostasis
regulation of innate immune response
negative regulation of fatty acid oxidation
negative regulation of glucose import
negative regulation of neurogenesis
protein homotetramerization
positive regulation of phagocytosis, engulfment
positive regulation of cold-induced thermogenesis
negative regulation of cytokine production involved in inflammatory response
negative regulation of cellular response to insulin stimulus
positive regulation of macropinocytosis
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of G1/S transition of mitotic cell cycle
negative regulation of neural precursor cell proliferation
cell proliferation
cell cycle
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support