In Western blot applications, this antibody detects a band at ~27kDa. A suggested positive control is Jurkat cell lysate.
PA5-19976 can be used with blocking peptide PEP-0101.
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1-a (for TNF related death ligand 1-a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kappa-B, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
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Protein Aliases: A proliferation-inducing ligand; APRIL; CD256; TALL-2; TALL2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNFSF13; TRDL-1; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand 7B; Tumor necrosis factor ligand superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; UNQ383/PRO715
Gene Aliases: 2310026N09Rik; APRIL; CD256; TALL-2; TALL2; TNFSF13; TNLG7B; TRDL-1; Trdl1; UNQ383/PRO715; ZTNF2