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Invitrogen
APRIL Polyclonal Antibody
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Product Details
PA5-19976
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to amino acids within a extracellular domain of human APRIL.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blot applications, this antibody detects a band at ~27kDa. A suggested positive control is Jurkat cell lysate.
PA5-19976 can be used with blocking peptide PEP-0101.
Target Information
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for A PRoliferation-Inducing Ligand), TALL2 (for TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A proliferation-inducing ligand; APRIL; APRIL delta; APRIL epsilon; CD256; ligand; TALL-2; TNF ligand superfamily, member 13; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNFSF13; TRDL-1; TRDL-1alpha; tumor necrosis factor-like ligand; TRDL-1beta; tumor necrosis factor-like ligand; TRDL-1gamma; tumor necrosis factor-like ligand; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand 7B; Tumor necrosis factor ligand superfamily member 13; tumor necrosis factor superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; unnamed protein product
Gene Aliases: 2310026N09Rik; APRIL; CD256; TALL-2; TALL2; TNFSF13; TNLG7B; TRDL-1; Trdl1; UNQ383/PRO715; ZTNF2
UniProt ID: (Human) O75888, (Mouse) Q9D777
Entrez Gene ID: (Human) 8741, (Rat) 287437, (Mouse) 69583
immunoglobulin production in mucosal tissue
positive regulation of germinal center formation
biological_process
positive regulation of cell proliferation
immunoglobulin mediated immune response
positive regulation of isotype switching to IgA isotypes
regulation of immune response
lymphocyte homeostasis
immune system process
immune response
cell communication
signal transduction
signaling
positive regulation of B cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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