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Immunogen sequence: QGRARASLC NLYNWRYKNL GNLPHVQLLP EFSTANAGLL YDFQLINVED FQGVGESEPN PYFYQNLGEA EYVVALFMYM CLLGYPADKI SILTTYNGQK HLIRDIINRR CGNNPLIGRP NKVTTVDRFQ GQQNDYILLS LVRTRAVGHL RDVRRLVVAM SRARLGLYIF ARVSLFQNCF ELTPAFSQLT ARPLHLHIIP TEPFPTTRKN GERPSHEVQI IKNMPQMANF VYNMYMHLIQ TTHHYHQTLL QLPPAMVEEG EEVQNQETEL ETEEEAMTVQ ADIIPSPTDT SCRQETPAFQ TDTTPSETGA TSTPEAIPAL SETTPTVVGA VSAPAEANTP QDATSAPEET K (1136-1485 aa encoded by BC127111)
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: aquarius homolog; functional spliceosome-associated protein 164; IBP160; Intron-binding protein of 160 kDa; RNA helicase aquarius
Gene Aliases: AQR; fSAP164; IBP160; KIAA0560
UniProt ID: (Human) O60306
Entrez Gene ID: (Human) 9716
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