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AQR Antibody (PA5-109403) in IHC (P)
Immunohistochemistry analysis of AQR in paraffin-embedded human lung cancer. Samples were incubated with AQR Polyclonal antibody (Product # PA5-109403) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-109403
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human AQR (NP_055506.1).
Conjugate
Form
Liquid
Concentration
1.95 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854814
Product Specific Information
Immunogen sequence: KEFLLELLVS RHERRISQIQ QLNQMPLYPT EKIIWDENIV PTEYYSGEGC LALPKLNLQF LTLHDYLLRN FNLFRLESTY EIRQDIEDSV SRMKPWQSEY GGVVFGGWAR MAQPIVAFTV VEVAKPNIGE NWPTRVRADV TINLNVRDHI KDEWEGLRKH DVCFLITVRP TKPYGTKFDR RRPFIEQVGL VYVRGCEIQG MLDDKGRVIE DGPEPRPNLR GESRTFRVFL DPNQYQQDMT NTIQNGAEDV YETFNIIMRR KPKENNFKAV LETIRNLMNT DCVVPDWLHD IILGYGDPSS A
Target Information
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aquarius homolog; functional spliceosome-associated protein 164; IBP160; intron-binding protein aquarius; Intron-binding protein of 160 kDa; RNA helicase aquarius
Gene Aliases: AQR; AW495846; fSAP164; IBP160; KIAA0560; mKIAA0560
UniProt ID: (Human) O60306, (Mouse) Q8CFQ3
Entrez Gene ID: (Human) 9716, (Mouse) 11834, (Rat) 366163
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