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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human AQR (NP_055506.1). |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
3.57 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2854814 |
Sequence of this protein is as follows: KEFLLELLVS RHERRISQIQ QLNQMPLYPT EKIIWDENIV PTEYYSGEGC LALPKLNLQF LTLHDYLLRN FNLFRLESTY EIRQDIEDSV SRMKPWQSEY GGVVFGGWAR MAQPIVAFTV VEVAKPNIGE NWPTRVRADV TINLNVRDHI KDEWEGLRKH DVCFLITVRP TKPYGTKFDR RRPFIEQVGL VYVRGCEIQG MLDDKGRVIE DGPEPRPNLR GESRTFRVFL DPNQYQQDMT NTIQNGAEDV YETFNIIMRR KPKENNFKAV LETIRNLMNT DCVVPDWLHD IILGYGDPSS A
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: aquarius homolog; functional spliceosome-associated protein 164; IBP160; intron-binding protein aquarius; Intron-binding protein of 160 kDa; RNA helicase aquarius
Gene Aliases: AQR; AW495846; fSAP164; IBP160; KIAA0560; mKIAA0560
UniProt ID: (Human) O60306, (Mouse) Q8CFQ3
Entrez Gene ID: (Human) 9716, (Mouse) 11834, (Rat) 366163
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