This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Recommended positive controls: HepG2.
Predicted reactivity: Mouse (89%), Rat (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 114 kDa Rho-specific guanine nucleotide exchange factor; p114-Rho-GEF; p114RhoGEF; Rho guanine nucleotide exchange factor 18; Rho-specific guanine nucleotide exchange factor p114; Rho/Rac guanine nucleotide exchange factor (GEF) 18; SA-RhoGEF; Septin-associated RhoGEF
Gene Aliases: AI467246; ARHGEF18; D030053O22Rik; KIAA0521; P114-RhoGEF