The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
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Protein Aliases: ADP ribosylation factor like 1; ADP-ribosylation factor like GTPase 1; ADP-ribosylation factor-like 1; ADP-ribosylation factor-like protein 1; ADP-ribosylation-like 1; ARFL1; ARL1
Gene Aliases: 2310008D22Rik; ARFL1; ARL1; AU019749