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Invitrogen
ARPC2 Polyclonal Antibody
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FIGURE: 1 / 2
ARPC2 Antibody (PA5-88041) in IHC (P)
Immunohistochemistry analysis of ARPC2 in paraffin-embedded rat spleen. Samples were incubated with ARPC2 Polyclonal antibody (Product # PA5-88041) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-88041
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ARPC2 (NP_6906011)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR; Positive Samples: A375, U-87MG, HT-29, SGC-7901, Mouse heart, Mouse lung, Mouse spleen, Mouse thymus, Rat heart; Cellular Location: Cell junction, Cell projection, Cytoplasm, cytoskeleton, synapse, synaptosome
Target Information
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 34 kD subunit of the Arp2/3 protein complex; actin related protein 2/3 complex, subunit 2, 34kDa; arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34; NB4 apoptosis/differentiation related protein; p34-ARC; testis tissue sperm-binding protein Li 53e; unnamed protein product
Gene Aliases: 2210023N03Rik; 34kDa; ARC34; p34-Arc; p34Arc; PNAS-139; PRO2446
UniProt ID: (Human) O15144, (Mouse) Q9CVB6
Entrez Gene ID: (Human) 10109, (Rat) 301511, (Mouse) 76709
positive regulation of lamellipodium assembly
actin filament polymerization
Arp2/3 complex-mediated actin nucleation
positive regulation of cellular component biogenesis
actin cortical patch organization
positive regulation of cellular component organization
actin polymerization-dependent cell motility
positive regulation of smooth muscle cell migration
regulation of actin filament polymerization
positive regulation of actin filament polymerization
positive regulation of protein complex assembly
regulation of actin cytoskeleton organization
response to silicon dioxide
intracellular signal transduction
cellular response to platelet-derived growth factor stimulus
positive regulation of filopodium assembly
cellular response to hydrogen peroxide
cellular response to epidermal growth factor stimulus
positive regulation of podosome assembly
cellular response to rapamycin
positive regulation of protein targeting to membrane
positive regulation of substrate adhesion-dependent cell spreading
cellular response to nerve growth factor stimulus
positive regulation of barbed-end actin filament capping
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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