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Abnova
ARRB1 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 1
ARRB1 Antibody (H00000408-D01P) in WB
Western Blot analysis of ARRB1 expression in transfected 293T cell line (H00000408-T02) by ARRB1 MaxPab polyclonal antibody.
Lane 1: ARRB1 transfected lysate(47.10 KDa).
Lane 2: Non-transfected lysate.
Lane 1: ARRB1 transfected lysate(47.10 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00000408-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARRB1 (NP_004032.2, 1 a.a. approximately 418 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKEEEEDGT GSPQLNNR
Target Information
Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: arrestin; arrestin 2; Arrestin beta-1; beta-arrestin; Beta-arrestin-1; Non-visual arrestin-2; unnamed protein product
Gene Aliases: ARB1; ARR1; ARRB1
UniProt ID: (Human) P49407
Entrez Gene ID: (Human) 408
G-protein coupled receptor binding
transcription coactivator activity
histone acetyltransferase activity
enzyme inhibitor activity
GTPase activator activity
insulin-like growth factor receptor binding
protein binding
enzyme binding
ubiquitin protein ligase binding
angiotensin receptor binding
binding, bridging
arrestin family protein binding
positive regulation of protein phosphorylation
desensitization of G-protein coupled receptor protein signaling pathway
G-protein coupled receptor internalization
positive regulation of receptor internalization
regulation of transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
signal transduction
sensory perception
negative regulation of signal transduction
positive regulation of cardiac muscle hypertrophy
protein transport
protein ubiquitination
negative regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
positive regulation of Rho protein signal transduction
stress fiber assembly
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of ERK1 and ERK2 cascade
positive regulation of intracellular signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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