PA5-29476 targets ASB2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29476 immunogen is recombinant fragment corresponding to a region within amino acids 210 and 453 of Human ASB2.
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The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
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Protein Aliases: Ankyrin repeat and SOCS box protein 2; ankyrin repeat and SOCS box-containing protein 2a; ASB-2
Gene Aliases: ASB-2; ASB2
UniProt ID: (Human) Q96Q27
Entrez Gene ID: (Human) 51676