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Invitrogen
ASC1 Polyclonal Antibody
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FIGURE: 1 / 2
ASC1 Antibody (PA5-144669) in WB
Western blot analysis of ASC1 in different various lysates. Lane 1: A549 cell lysate; Lane 2: Hela cell lysate; Lane 3: U87MG cell lysate; Lane 4: 293T cell lysate; Lane 5: HL-60 cell lysate; Lane 6: HepG2 cell lysate Lysates/proteins at 10 µg/Lane. Predicted band size: 66 kDa. Observed band size: 66 kDa. Exposure time: 2 minutes; 4-20% SDS-PAGE gel. Primary antibody ASC1 polyclonal antibody (Product # PA5-144669) with a dilution of 1:1,000 was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG-HRP Secondary Antibod... View More
Product Details
PA5-144669
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human ASC1 aa 1-581/581.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive control: A549 cell lysate, Hela cell lysate, U87MG cell lysate, 293T cell lysate, HL-60 cell lysate, HepG2 cell lysate, rat liver tissue lysates.
Predicted band size: 66 kDa
Subcellular Location: Nucleus, Cytoplasm, cytosol, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Information
Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activating signal cointegrator 1; ASC-1; Thyroid receptor-interacting protein 4; TR-interacting protein 4; TRIP-4; unnamed protein product; zinc finger, C2HC5-type
Gene Aliases: ASC-1; ASC1; HsT17391; MDCDC; RQT4; SMABF1; TRIP4; ZC2HC5
UniProt ID: (Human) Q15650
Entrez Gene ID: (Human) 9325, (Rat) 315769
protease binding
transcription coactivator activity
protein binding
zinc ion binding
ligand-dependent nuclear receptor binding
protein kinase binding
estrogen receptor binding
histone acetyltransferase binding
ubiquitin-like protein ligase binding
metal ion binding
transcription cofactor
gene-specific transcriptional regulator
regulation of transcription, DNA-templated
intracellular estrogen receptor signaling pathway
ribosome disassembly
regulation of myoblast differentiation
positive regulation of transcription, DNA-templated
rescue of stalled ribosome
ribosome-associated ubiquitin-dependent protein catabolic process
toxin transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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