Immunogen sequence: VIDDESDYFA SDSNQWLSKL ERETLQKREE ELRELRHASR LSKKVTIDFA GRKILEEENS LAEYHSRLDE TIQAIANGTL NQPLTKLDRS SEEPLGVLVN PNMYQSPPQW VDHTGAASQK KAFRSSGFGL EFNSFQHQLR IQDQEFQEGF DGGWCLSVHQ PWASLLVRGI KRVEGRSWYT PHRGRLWIAA TAKKPSPQEV SELQATYRLL RGKDVEFPND YPSGCLLGCV DLIDCLSQKQ FKEQFPDISQ ESDSPFVFIC KNPQEMVVKF PIKGNPKIWK LDSKIHQGAK KGLMKQNKAV; Positive Samples: A-549, HeLa, LO2, Mouse liver, Mouse testis, Mouse brain, Rat testis, Rat brain; Cellular Location: Cytoplasm, Nucleus, centrosome, cytoskeleton, cytosol, microtubule organizing center
Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activating signal cointegrator 1; ASC-1; Thyroid receptor-interacting protein 4; TR-interacting protein 4; transcription coactivator Asc1; TRIP-4; zinc finger, C2HC5-type
Gene Aliases: 4930558E03Rik; ASC-1; ASC1; BB191711; HsT17391; SMABF1; TRIP4; ZC2HC5