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Product Details
CL488-11529
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ASCC2 fusion protein Ag2100
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: RRKATDAKD PSVIEEPNGE PNGVTVTAEA VSQASSHPEN SEEEECMGAA AAVGPAMCGV ELDSLISQVK DLLPDLGEGF ILACLEYYHY DPEQVINNIL EERLAPTLSQ LDRNLDREMK PDPTPLLTSR HNVFQNDEFD VFSRDSVDLS RVHKGKSTRK EENTRSLLND KRAVAAQRQR YEQYSVVVEE VPLQPGESLP YHSVYYEDEY DDTYDGNQVG ANDADSDDEL ISRRPFTIPQ VLRTKVPREG QEEDDDDEED DADEEAPKPD HFVQDPAVLR EKAEARRMAF LAKKGYRHDS STAVAGSPRG HGQSRETTQE RRKKEANKAT RANHNRRTMA DRKRSKGMIP S
Target Information
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activating signal cointegrator 1 complex subunit 2; ASC-1 complex subunit P100; Trip4 complex subunit p100
Gene Aliases: 1700011I11Rik; 2610034L15Rik; AI482016; ASC1P100; ASCC2; AW046480; p100; RGD1561422; RQT3
UniProt ID: (Human) Q9H1I8, (Mouse) Q91WR3
Entrez Gene ID: (Human) 84164, (Mouse) 75452, (Rat) 498402
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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