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Immunogen sequence: LASESDTAD QEDLDVEDDH EEQPSNQTVR RPQAVIEDAV ATSGVSTLSS TVSHDSQSAH RSLNVQLGRM KIETNRLLEE LVRKEKELQA LLHRAIEEKD QEIKHLKLKS QPIEIPELPV FHLNSSGTNT EDSELTDWLR VNGADEDTIS RFLAEDYTLL DVLYYVTRDD LKCLRLRGGM LCTLWKAIID FRNKQT (1180-1374 aa encoded by BC054503)
MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
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Protein Aliases: apoptosis signal regulating kinase 1; Apoptosis signal-regulating kinase 1; ASK 1; ASK-1; EC 188.8.131.52; kinase ASK1; M3K5; MAP/ERK kinase kinase 5; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5; mitogen activated protein kinase kinase kinase 5; Mitogen-activated protein kinase kinase kinase 5; RP3-325F22.4
Gene Aliases: 7420452D20Rik; ASK; ASK1; MAP3K5; MAPKKK5; MEKK5
Molecular Function: non-receptor serine/threonine protein kinase