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Proteintech
ASL Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
16645-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ASL Fusion Protein Ag10007 (114-464 aa encoded by BC008195)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NDQVVTDLR LWMRQTCSTL SGLLWELIRT MVDRAEAERD VLFPGYTHLQ RAQPIRWSHW ILSHAVALTR DSERLLEVRK RINVLPLGSG AIAGNPLGVD RELLRAELNF GAITLNSMDA TSERDFVAEF LFWASLCMTH LSRMAEDLIL YCTKEFSFVQ LSDAYSTGSS LMPQKKNPDS LELIRSKAGR VFGRCAGLLM TLKGLPSTYN KDLQEDKEAV FEVSDTMSAV LQVATGVIST LQIHQENMGQ ALSPDMLATD LAYYLVRKGM PFRQAHEASG KAVFMAETKG VALNQLSLQE LQTISPLFSG DVICVWDYGH SVEQYGALGG TARSSVDWQI RQVRALLQAQ QA (114-464 aa encoded by BC008195)
Target Information
ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: argininosuccinase; argininosuccinate lyase; argininosuccinate lyase (EC 4.3.2.1); arginosuccinase; ASAL; unnamed protein product
Gene Aliases: 2510006M18Rik; ASAL; ASLD
UniProt ID: (Human) P04424, (Mouse) Q91YI0, (Rat) P20673
Entrez Gene ID: (Human) 435, (Mouse) 109900, (Rat) 59085
urea cycle
arginine metabolic process
arginine biosynthetic process
positive regulation of nitric oxide biosynthetic process
L-amino acid metabolic process
liver development
cellular amino acid metabolic process
locomotory behavior
post-embryonic development
ammonia assimilation cycle
response to nutrient levels
kidney development
midgut development
response to nutrient
response to xenobiotic stimulus
response to toxic substance
response to zinc ion
response to amine
response to lipopolysaccharide
response to peptide hormone
response to steroid hormone
response to growth hormone
diaphragm development
cellular response to ammonium ion
cellular response to cAMP
cellular response to interferon-gamma
cellular response to tumor necrosis factor
cellular response to glucagon stimulus
cellular response to glucocorticoid stimulus
cellular response to hypoxia
cellular response to dexamethasone stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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