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AT2R2 Polyclonal Antibody

View all (10) AGTR2 antibodies

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AT2R2 Polyclonal Antibody

Product Details

BS-2133R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human angiotensin II receptor type 2, amino acids 151-250.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Angiotensin ii at2; angiotensin II receptor, type 2; angiotensin II type 2 receptor; Angiotensin II type-2 receptor; angiotensin receptor 2; AT2; AT2 receptor; Type-2 angiotensin II receptor

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Gene Aliases: AGTR2; AI316812; AT2; AT2-R; AT2R; AT2R; ATGR2; AW107640; MRX88

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UniProt ID: (Human) P50052, (Rat) P35351, (Mouse) P35374

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Entrez Gene ID: (Human) 186, (Rat) 24182, (Mouse) 11609

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Function(s)
angiotensin type II receptor activity protein binding transcription factor binding peptide hormone binding receptor antagonist activity G-protein alpha-subunit binding signal transducer activity G-protein coupled receptor activity G-protein coupled receptor
Process(es)
blood vessel remodeling regulation of systemic arterial blood pressure by circulatory renin-angiotensin renin-angiotensin regulation of aldosterone production vasodilation by angiotensin involved in regulation of systemic arterial blood pressure brain renin-angiotensin system cellular sodium ion homeostasis inflammatory response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger nitric oxide mediated signal transduction brain development regulation of blood pressure positive regulation of cell proliferation negative regulation of heart rate negative regulation of norepinephrine secretion cerebellar cortex development negative regulation of cell growth negative regulation of icosanoid secretion positive regulation of phosphoprotein phosphatase activity intracellular signal transduction regulation of metanephros size exploration behavior positive regulation of renal sodium excretion aldosterone secretion angiotensin-activated signaling pathway dopamine biosynthetic process regulation of transcription factor import into nucleus negative regulation of blood vessel endothelial cell migration positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated positive regulation of vasodilation negative regulation of fibroblast proliferation positive regulation of cytokine secretion positive regulation of nitric-oxide synthase activity negative regulation of neurotrophin TRK receptor signaling pathway cell growth involved in cardiac muscle cell development cellular response to dexamethasone stimulus positive regulation of metanephric glomerulus development positive regulation of branching involved in ureteric bud morphogenesis extracellular negative regulation of signal transduction positive regulation of extrinsic apoptotic signaling pathway kidney development response to organonitrogen compound neuron differentiation negative regulation of neuron apoptotic process kidney morphogenesis signal transduction regulation of vasodilation regulation of apoptotic process
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