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Proteintech
ATF4 Polyclonal Antibody
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Product Details
28657-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATF4 fusion protein Ag29844
Conjugate
Form
Liquid
Concentration
833 µg/mL
Amount
124.95 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Activating transcription factor 4; ATF 4; ATF4; ATF4 protein; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB 2; CREB-2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; OTTHUMP00000199130; tax-re; tax-responsive enhancer element B67; Tax-responsive enhancer element-binding protein 67; TaxREB67; unnamed protein product
Gene Aliases: ATF4; CREB-2; CREB2; TAXREB67; TXREB
UniProt ID: (Human) P18848
Entrez Gene ID: (Human) 468
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
cAMP response element binding protein binding
protein kinase binding
identical protein binding
leucine zipper domain binding
sequence-specific DNA binding
protein heterodimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
general transcription initiation factor binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
gluconeogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular calcium ion homeostasis
gamma-aminobutyric acid signaling pathway
circadian rhythm
response to toxic substance
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
neuron differentiation
bone mineralization
endoplasmic reticulum unfolded protein response
response to nutrient levels
negative regulation of translational initiation in response to stress
circadian regulation of gene expression
cellular response to amino acid starvation
cellular response to oxidative stress
cellular response to UV
response to endoplasmic reticulum stress
embryonic hemopoiesis
PERK-mediated unfolded protein response
cellular response to glucose starvation
mRNA transcription from RNA polymerase II promoter
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of potassium ion transport
positive regulation of neuron apoptotic process
regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
rhythmic process
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of biomineral tissue development
lens fiber cell morphogenesis
L-asparagine metabolic process
cellular response to hypoxia
mitochondrial respiratory chain supercomplex assembly
negative regulation of cold-induced thermogenesis
integrated stress response signaling
HRI-mediated signaling
GDF15-GFRAL signaling pathway
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of vascular associated smooth muscle cell apoptotic process
cellular response to leucine starvation
response to manganese-induced endoplasmic reticulum stress
positive regulation of sodium-dependent phosphate transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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