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Proteintech
ATM Polyclonal Antibody
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Product Details
27156-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATM Fusion Protein Ag25909 (2407-2709 aa encoded by BC137169)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SSEFENKQA LLKRAKEEVG LLREHKIQTN RYTVKVQREL ELDELALRAL KEDRKRFLCK AVENYINCLL SGEEHDMWVF RLCSLWLENS GVSEVNGMMK RDGMKIPTYK FLPLMYQLAA RMGTKMMGGL GFHEVLNNLI SRISMDHPHH TLFIILALAN ANRDEFLTKP EVARRSRITK NVPKQSSQLD EDRTEAANRI ICTIRSRRPQ MVRSVEALCD AYIILANLDA TQWKTQRKGI NIPADQPITK LKNLEDVVVP TMEIKVDHTG EYGNLVTIQS FKAEFRLAGG VNLPKIIDCV GSDG (2407-2709 aa encoded by BC137169)
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens. The ATM's C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction. Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair. Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A-T mutated; AT mutated; AT mutated protein; Ataxia t; Ataxia telangiectasia mutated; DKFZp781A0353; EC 2.7.1.37; MGC74674; Serine-protein kinase ATM; TEL1, telomere maintenance 1, homolog
Gene Aliases: AT1; ATA; ATC; ATD; ATDC; ATE; ATM; TEL1; TELO1
UniProt ID: (Human) Q13315
Entrez Gene ID: (Human) 472
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
response to hypoxia
somitogenesis
pre-B cell allelic exclusion
DNA replication
DNA repair
double-strand break repair via nonhomologous end joining
protein phosphorylation
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
telomere maintenance via telomerase
cell cycle arrest
mitotic spindle assembly checkpoint
reciprocal meiotic recombination
signal transduction
brain development
heart development
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to ionizing radiation
regulation of autophagy
histone phosphorylation
peptidyl-serine phosphorylation
negative regulation of B cell proliferation
positive regulation of telomere maintenance via telomerase
positive regulation of histone phosphorylation
V(D)J recombination
phosphatidylinositol-3-phosphate biosynthetic process
peptidyl-serine autophosphorylation
lipoprotein catabolic process
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of neuron apoptotic process
meiotic telomere clustering
protein autophosphorylation
oocyte development
neuron apoptotic process
regulation of telomerase activity
histone mRNA catabolic process
cellular response to gamma radiation
cellular response to X-ray
cellular response to nitrosative stress
signal transduction involved in mitotic G2 DNA damage checkpoint
replicative senescence
establishment of RNA localization to telomere
establishment of macromolecular complex localization to telomere
regulation of cellular response to heat
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
negative regulation of telomere capping
positive regulation of telomere maintenance via telomere lengthening
positive regulation of telomerase catalytic core complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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