Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Proteintech
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 13 publications 13 publications |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | View 2 publications 2 publications |
Flow Cytometry (Flow) |
0.2 µg/1x10^6 cells | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | View 1 publication 1 publication |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
ATP citrate lyase Fusion Protein Ag7709 (751-1101 aa encoded by BC006195) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.17 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MFSSEVQFG HAGACANQAS ETAVAKNQAL KEAGVFVPRS FDELGEIIQS VYEDLVANGV IVPAQEVPPP TVPMDYSWAR ELGLIRKPAS FMTSICDERG QELIYAGMPI TEVFKEEMGI GGVLGLLWFQ KRLPKYSCQF IEMCLMVTAD HGPAVSGAHN TIICARAGKD LVSSLTSGLL TIGDRFGGAL DAAAKMFSKA FDSGIIPMEF VNKMKKEGKL IMGIGHRVKS INNPDMRVQI LKDYVRQHFP ATPLLDYALE VEKITTSKKP NLILNVDGLI GVAFVDMLRN CGSFTREEAD EYIDIGALNG IFVLGRSMGF IGHYLDQKRL KQGLYRHPWD DISYVLPEHM SM (751-1101 aa encoded by BC006195)
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACL; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; Citrate cleavage enzyme
Gene Aliases: A730098H14Rik; ACL; ACLY; ATPCL; AW538652; CLATP
UniProt ID: (Human) P53396, (Mouse) Q91V92, (Rat) P16638
Entrez Gene ID: (Human) 47, (Mouse) 104112, (Rat) 24159
Molecular Function:
transferase
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