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Proteintech
ATP1A1 Polyclonal Antibody
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Product Details
14418-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP1A1 Fusion Protein Ag5763 (347-680 aa encoded by BC050359)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TAKRMARKN CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN QIHEADTTEN QSGVSFDKTS ATWLALSRIA GLCNRAVFQA NQENLPILKR AVAGDASESA LLKCIELCCG SVKEMRERYA KIVEIPFNST NKYQLSIHKN PNTSEPQHLL VMKGAPERIL DRCSSILLHG KEQPLDEELK DAFQNAYLEL GGLGERVLGF CHLFLPDEQF PEGFQFDTDD VNFPIDNLCF VGLISMIDPP RAAVPDAVGK CRSAGIKVIM VTGDHPITAK AIAKGVGIIS EGNETVEDIA ARLNIPVSQV NPRDAKACVV HGSDLKDMTS EQLDD (347-680 aa encoded by BC050359)
Target Information
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP1B; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; G00-119-711; MGC1798; Na(+)/K(+) ATPase alpha-1 subunit; Na+ K+ ATPase alpha subunit; Na+/K+ ATPase 1; Na+/K+ ATPase Alpha; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; RP4-655J12.1; Sodium Potassium ATPase; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide; Sodium/potassium-transporting ATPase subunit alpha-1; unnamed protein product
Gene Aliases: ATP1A1; Atpa-1; BC010319; CMT2DD; HOMGSMR2; Nkaa1b
UniProt ID: (Human) P05023, (Rat) P06685, (Mouse) Q8VDN2
Entrez Gene ID: (Human) 476, (Rat) 24211, (Mouse) 11928
nucleotide binding
sodium:potassium-exchanging ATPase activity
protein binding
ATP binding
potassium-transporting ATPase activity
phosphatase activity
ATPase activity
potassium ion binding
sodium ion binding
ion channel binding
metal ion binding
protein heterodimerization activity
chaperone binding
steroid hormone binding
protein kinase binding
protein domain specific binding
ankyrin binding
ADP binding
phosphatidylinositol 3-kinase binding
hydrolase activity
primary active transporter
regulation of the force of heart contraction
regulation of sodium ion transport
ion transport
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
osmosensory signaling pathway
regulation of blood pressure
response to xenobiotic stimulus
establishment or maintenance of transmembrane electrochemical gradient
cellular cation homeostasis
cellular potassium ion homeostasis
negative regulation of glucocorticoid biosynthetic process
sodium ion transmembrane transport
sodium ion export from cell
negative regulation of heart contraction
positive regulation of heart contraction
positive regulation of striated muscle contraction
sodium ion homeostasis
relaxation of cardiac muscle
heart contraction
cellular response to steroid hormone stimulus
potassium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
hydrogen ion transmembrane transport
response to glycoside
potassium ion import across plasma membrane
potassium ion import
energy coupled proton transmembrane transport, against electrochemical gradient
dephosphorylation
response to drug
cardiac muscle contraction
membrane hyperpolarization
cellular response to mechanical stimulus
regulation of cardiac muscle cell contraction
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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