PA5-29719 targets Sodium Potassium ATPase Beta 1 in IHC (P) and WB applications and shows reactivity with Human, mouse, and Rat samples.
The PA5-29719 immunogen is recombinant fragment corresponding to a region within amino acids 83 and 303 of Human Sodium Potassium ATPase Beta 1.
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The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Protein Aliases: adenosinetriphosphatase; ATP1B; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+); Beta 1-subunit of Na(+),K(+)-ATPase; K(+)-ATPase; K-ATPase beta-1 polypeptide; Na; Na, K-ATPase beta-1 polypeptide; Na,K-ATPase beta 1 subunit; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase beta-1 subunit; Sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; Sodium/potassium-transporting ATPase subunit beta-1
Gene Aliases: ATP1B; ATP1B1; Atp4b; Atpb; Atpb-1; ATPBS; NKbeta1