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Invitrogen
ATP6V0C Polyclonal Antibody
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Product Details
PA5-23972
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 100-126 amino acids from the C-terminal region of human ATP6V0C
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine, equine and rat based on sequence homology.
Target Information
ATP6V0C is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. ATP6V0C encodes the V0 subunit c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP6V0C; ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa; ATPase, H+ transporting, lysosomal 16kD, V0 subunit C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATPase, H+ transporting, lysosomal 2; H(+)-ATPase (mvp); H(+)-transporting two-sector ATPase, 16 kDa subunit; PL16; V-ATPase 16 kDa proteolipid subunit; V-ATPase 16 kDa proteolipid subunit c; V-type proton ATPase 16 kDa proteolipid subunit; V-type proton ATPase 16 kDa proteolipid subunit c; vacuolar ATP synthase 16 kDa proteolipid subunit; vacuolar H+ ATPase proton channel subunit; vacuolar proton pump 16 kDa proteolipid subunit; Vacuolar proton pump 16 kDa proteolipid subunit c
Gene Aliases: ATP6C; Atp6c2; ATP6L; ATP6V0C; ATPL; Atpl-rs1; EPEO3; Mvp; PL16; VATL; Vma3; VPPC
UniProt ID: (Human) P27449, (Mouse) P63082
Entrez Gene ID: (Human) 527, (Mouse) 11984
ion transport
vacuolar acidification
lysosomal lumen acidification
ATP synthesis coupled proton transport
regulation of macroautophagy
positive regulation of Wnt signaling pathway
endosomal lumen acidification
intracellular pH reduction
Golgi lumen acidification
synaptic vesicle lumen acidification
hydrogen ion transmembrane transport
transport
ATP hydrolysis coupled proton transport
proton transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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