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Agrisera
ATPase AAA2 domain Polyclonal Antibody
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FIGURE: 1 / 2
ATPase AAA2 domain Antibody (AS11-1754) in WB
The 20 µg of soluble proteins from 3-week old Solanum tuberosum (1) and Arabidopsis thaliana (2), one-week old Lupinus angustifolius (3), Pisum sativum (4) and Zea mays L. (5) leaves extracted with buffer containing 50 мM Hepes-KOH, p H 7.5,330 мM sorbitol, 2 мM EDTA, 1 мM Mg Cl 2,5 мM ascorbate, 0.05% BSA were mixed with sample buffer and denatured for 5 min at 70°C. Samples were separated on 10% SDS-PAGE and blotted 1 h to nitrocellulose membrane (Amersham Protran) using tank wet-transfer (Bio-Rad) in standard transfer buffer in presence... View More
Product Details
AS11-1754
Product Specifications
Species Reactivity
Algae,
Bacteria,
Plant
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
KLH-conjugated synthetic peptide derived from proteins containing AAA2 domain.
Conjugate
Form
Lyophilized
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 200 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana, Chlamydomonas reinhardtii, Lupinus angustifolius, Pisum sativum, Solanum tuberosum, Synechococcus sp. PCC 7942, Zea mays L.
Target Information
ATPase family AAA domain containing 2 (ATAD2) encodes a predominantly nuclear chromatin-associated AAA+ ATPase that is enriched on chromatin during S phase, where it can localize to replication sites. The ATAD2 protein is a large multidomain factor comprising an N-terminal acidic region followed by two tandem AAA+ ATPase modules (often referred to as AAA1 and AAA2), and a C-terminal bromodomain that adopts the canonical four-helix bromodomain fold and binds acetyl-lysine marks on histones (including di-acetylated histone H4K5ac/K12ac associated with newly synthesized histones). Through its bromodomain-mediated recognition of acetylated histones and ATPase-driven remodeling/chaperone-like activity, ATAD2 functions as a chromatin regulator that promotes chromatin dynamics and supports DNA replication; it also acts as a transcriptional coregulator, including in pathways controlling cell-cycle gene expression, consistent with roles in coupling epigenetic state to proliferation programs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATHSP101; F1O17.2; F1O17_2; HOT1; HSP101
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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