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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a portion of human Ataxia and Rad3 related encoded within exon 5.|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris phosphate/tris citrate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.03-0.07 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-20141 detects ATR in human and mouse samples.
PA1-20141 has been successfully used in Western blot procedures.
The PA1-20141 immunogen is a synthetic peptide corresponding to a portion of human Ataxia and Rad3 related encoded within exon 5.
Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR is a member of the DNA-PK kinases closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes. Several known components of the NuRD complex including histone deacetylase 1 (HDAC1), HDAC2, and CHD4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ataxia telangiectasia and Rad3-related protein; FRAP-related protein-1; FRP1; MEC1; MEC1, mitosis entry checkpoint 1, homolog; SCKL; SCKL1; serine/threonine-protein kinase ATR
ATR; FCTCS; FRP1; MEC1; SCKL; SCKL1