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Invitrogen
AVP Polyclonal Antibody
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Product Details
PA5-112845
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Vasopressin-neurophysin 2-copeptin protein (126-164AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antidiuretic hormone; arginine vasopressin (Diabetes insipidus), same as Di (conflicting physical mapping); AVP-NPII; copeptin; neurohypophyseal; prepro-arginine-vasopressin-neurophysin II; prepro-AVP-NP II; prepropressophysin; preprovasopressin-neurophysin; unnamed protein product; Vasopressin; Vasopressin-neurophysin 2-copeptin; vasopressin-neurophysin II-copeptin; vasopressin-neurophysin prepropeptide
Gene Aliases: ADH; ARVP; AVP; AVP-NPII; AVRP; DI; Vas; VP
UniProt ID: (Human) P01185, (Rat) P01186
Entrez Gene ID: (Human) 551, (Rat) 24221
protein kinase activity
receptor binding
hormone activity
neuropeptide hormone activity
neurohypophyseal hormone activity
protein binding
V1A vasopressin receptor binding
V1B vasopressin receptor binding
signal transducer activity
V2 vasopressin receptor binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
neuropeptide
maternal aggressive behavior
positive regulation of systemic arterial blood pressure
generation of precursor metabolites and energy
water transport
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
negative regulation of female receptivity
grooming behavior
locomotory behavior
positive regulation of cell proliferation
response to xenobiotic stimulus
response to salt stress
positive regulation of gene expression
positive regulation of glutamate secretion
positive regulation of cell growth
positive regulation of prostaglandin biosynthetic process
positive regulation of cellular pH reduction
multicellular organismal response to stress
response to testosterone
response to nicotine
social behavior
intracellular signal transduction
vasoconstriction
maternal behavior
negative regulation of apoptotic process
response to ethanol
positive regulation of vasoconstriction
viral entry into host cell
multicellular organismal water homeostasis
response to electrical stimulus
negative regulation of transmission of nerve impulse
renal water absorption
regulation of blood vessel diameter
response to peptide
response to 2,3,7,8-tetrachlorodibenzodioxine
response to nerve growth factor
temperature homeostasis
protein phosphorylation
smooth muscle contraction
response to organic cyclic compound
positive regulation of cAMP biosynthetic process
positive regulation of peptidyl-serine phosphorylation
regulation of renal sodium excretion
hyperosmotic salinity response
penile erection
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
ERK1 and ERK2 cascade
protein kinase C signaling
negative regulation of release of cytochrome c from mitochondria
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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