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Invitrogen
AVPR1B Polyclonal Antibody
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Product Details
PA5-68474
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide from human protein at AA range: 271-320.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antidiuretic hormone receptor 1b; arginine vasopressin receptor 3; arginine vasopressin type 1b receptor; AVPR V1b; AVPR V3; pituitary vasopressin receptor 3; V1b receptor; V1bR; V3/V1b pituitary vasopressin receptor; Vasopressin V1b receptor; Vasopressin V3 receptor
Gene Aliases: AVPR1B; AVPR3; V1br; V3/V1b; VIBR; VPR3
UniProt ID: (Human) P47901, (Mouse) Q9WU02
Entrez Gene ID: (Human) 553, (Mouse) 26361, (Rat) 29462
regulation of systemic arterial blood pressure by vasopressin
G-protein coupled receptor signaling pathway
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
cellular response to hormone stimulus
positive regulation of vasoconstriction
response to peptide
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
positive regulation of glutamate secretion
positive regulation of cellular pH reduction
hyperosmotic salinity response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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