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Bioss
AVPR2 Polyclonal Antibody
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FIGURE: 1 / 1
AVPR2 Antibody (BS-10014R) in WB
Lane 1: mouse brain lysates Lane 2: mouse kidney lysates probed with Anti AVPR2 Polyclonal Antibody, Unconjugated (bs-10014R) at 1:200 in 4°C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90 min in 37°C. Predicted band 40 kD. Observed band size: 40 kD.
Product Details
BS-10014R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human AVPR2, amino acids 65-170.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Avpr2 is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. Avpr2 has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. Avpr2 can contract smooth muscle during parturition and lactation. Avpr2 is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. The activity of Avpr2 is mediated by G proteins which activate adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antidiuretic hormone receptor; Avp2r; AVPR V2; MGC126533; MGC138386; nephrogenic diabetes insipidus; Renal-type arginine vasopressin receptor; V2-renal V2R; V2R; Vasopressin receptor V2; Vasopressin V2 receptor
Gene Aliases: ADHR; AVPR2; DI1; DIR; DIR3; ND1; NDI; V2R; VPV2R
UniProt ID: (Human) P30518, (Mouse) O88721, (Rat) Q00788
Entrez Gene ID: (Human) 554, (Mouse) 12000, (Rat) 25108
regulation of systemic arterial blood pressure by vasopressin
positive regulation of systemic arterial blood pressure
renal water homeostasis
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
I-kappaB kinase/NF-kappaB signaling
excretion
hemostasis
positive regulation of cell proliferation
positive regulation of gene expression
telencephalon development
positive regulation of protein ubiquitination
interferon-gamma production
cellular response to hormone stimulus
response to cytokine
negative regulation of urine volume
negative regulation of renal sodium excretion
positive regulation of vasoconstriction
response to peptide
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of blood pressure
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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