Avpr2 is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. Avpr2 has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. Avpr2 can contract smooth muscle during parturition and lactation. Avpr2 is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. The activity of Avpr2 is mediated by G proteins which activate adenylate cyclase.
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Protein Aliases: Antidiuretic hormone receptor; Avp2r; AVPR V2; MGC126533; MGC138386; Renal-type arginine vasopressin receptor; V2-renal V2R; V2R; Vasopressin V2 receptor
Gene Aliases: ADHR; AVPR2; DI1; DIR; DIR3; NDI; V2R
UniProt ID: (Human) P30518
Entrez Gene ID: (Human) 554