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Alomone Labs, LTD

AXL (extracellular) Polyclonal Antibody

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AXL (extracellular) Polyclonal Antibody

Product Details

ATR-032-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:300
-

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)RLAYQGQDTPEVLMD, corresponding to amino acid residues 368-382 of human AXL, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Amount

160 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells. Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form. Increased plasma levels may be indicative of inflammation and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adhesion-related kinase; AXL oncogene; AXL transforming sequence/gene; AZF1; oncogene AXL; putative tyrosine kinase receptor; sAXL; soluble AXL; Tyrosine-protein kinase receptor UFO; ufo oncogene homolog; unnamed protein product

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Gene Aliases: AI323647; ARK; AXL; AXL3; JTK11; Tyro7; UFO

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UniProt ID: (Human) P30530, (Mouse) Q00993

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Entrez Gene ID: (Human) 558, (Mouse) 26362, (Rat) 308444

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Function(s)
nucleotide binding virus receptor activity phosphatidylserine binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups myosin heavy chain binding phosphatidylinositol 3-kinase binding protein heterodimerization activity growth factor binding transmembrane signal receptor
Process(es)
neuron migration natural killer cell differentiation negative regulation of cytokine production positive regulation of cytokine-mediated signaling pathway blood vessel remodeling immune system process phagocytosis apoptotic process inflammatory response signal transduction enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway spermatogenesis nervous system development positive regulation of signal transduction negative regulation of macrophage cytokine production cell migration forebrain cell migration cell differentiation platelet activation negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of natural killer cell differentiation secretion by cell erythrocyte homeostasis substrate adhesion-dependent cell spreading cellular response to interferon-alpha ovulation cycle negative regulation of apoptotic process apoptotic cell clearance negative regulation of neuron apoptotic process innate immune response lymphocyte activation viral entry into host cell vascular endothelial growth factor receptor signaling pathway cell maturation positive regulation of pinocytosis regulation of lymphocyte activation negative regulation of lymphocyte activation neuron apoptotic process establishment of localization in cell positive regulation of protein kinase B signaling vagina development cellular response to lipopolysaccharide dendritic cell differentiation neutrophil clearance mononuclear cell differentiation positive regulation of viral life cycle negative regulation of dendritic cell apoptotic process protein phosphorylation phosphorylation peptidyl-tyrosine phosphorylation cellular response to extracellular stimulus protein kinase B signaling cellular response to hydrogen peroxide cell proliferation organ regeneration tissue regeneration tissue remodeling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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