This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-27399 targets Adenosine kinase in IF, IHC (P), and WB applications and shows reactivity with Human, Rat and mouse samples.
The PA5-27399 immunogen is recombinant fragment corresponding to a region within amino acids 146 and 362 of Human Adenosine kinase.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2+ for activity.
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Protein Aliases: Adenosine 5'-phosphotransferase; Adenosine kinase; AK; testicular tissue protein Li 14
Gene Aliases: 2310026J05Rik; 5033405D03Rik; ADK; AI255373; AI987814; AK