PA5-34659 targets Aldolase B in ICC, IF, IHC (P), and WB applications and shows reactivity with Human, Mouse, and Rat samples.
The PA5-34659 immunogen is recombinant fragment corresponding to a region within amino acids 15 and 265 of Aldolase B (Uniprot ID#P05062).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Fructose-1,6-bisphosphate aldolase (EC 188.8.131.52) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ALDB; ALDO2; Aldolase 2; aldolase 2, B isoform; aldolase B; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; fructose-bisphosphatase; Fructose-bisphosphate aldolase B; Liver-type aldolase
Gene Aliases: ALDB; Aldo-2; ALDO2; ALDOB; BC016435; LIV10