Proteintech

Angiotensinogen Polyclonal Antibody, CoraLite® Plus 488

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Product Details

CL488-23972

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Angiotensinogen fusion protein Ag21121

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MRKRAPQSE MAPAGVSLRA TILCLLAWAG LAAGDRVYIH PFHLVIHNES TCEQLAKANA GKPKDPTFIP APIQAKTSPV DEKALQDQLV LVAAKLDTED KLRAAMVGML ANFLGFRIYG MHSELWGVVH GATVLSPTAV FGTLASLYLG ALDHTADRLQ AILGVPWKDK NCTSRLDAHK VLSALQAVQG LLVAQGRADS QAQLLLSTVV GVFTAPGLHL KQPFVQGLAL YTPVVLPRSL DFTELDVAAE KIDRFMQAVT GWKTGCSLTG ASVDSTLAFN TYVHFQGKMK GFSLLAEPQE FWVDNSTSVS VPMLSGMGTF QHWSDIQDNF SVTQVSFTES ACLLLIQPHY ASDLDKVEGL TFQQNSLNWM KKLSPRTIHL TMPQLVLQGS YDLQDLLAQA ELPAILHTEL NLQKLSNDRI RVGEVLNSIF FELEADEREP TESTQQLNKP EVLEVTLNRP FLFAVYDQSA TALHFLGRVA NPLSTA

Target Information

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8

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Gene Aliases: AGT; ANHU; SERPINA8

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UniProt ID: (Human) P01019

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Entrez Gene ID: (Human) 183

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Function(s)
serine-type endopeptidase inhibitor activity hormone activity protein binding growth factor activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding protease inhibitor
Process(es)
regulation of cell growth positive regulation of cytokine production kidney development blood vessel remodeling angiotensin maturation regulation of blood volume by renin-angiotensin renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin regulation of heart rate regulation of blood vessel size by renin-angiotensin renal system process angiotensin-mediated drinking behavior positive regulation of extracellular matrix constituent secretion cellular sodium ion homeostasis cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway activation of phospholipase C activity nitric oxide mediated signal transduction cell-cell signaling female pregnancy aging regulation of blood pressure positive regulation of activation of JAK2 kinase activity positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol esterification negative regulation of endopeptidase activity regulation of norepinephrine secretion positive regulation of phosphatidylinositol 3-kinase signaling artery smooth muscle contraction response to muscle activity involved in regulation of muscle adaptation negative regulation of angiogenesis regulation of vasoconstriction negative regulation of cell growth positive regulation of cellular protein metabolic process positive regulation of superoxide anion generation positive regulation of NAD(P)H oxidase activity negative regulation of tissue remodeling low-density lipoprotein particle remodeling catenin import into nucleus regulation of renal sodium excretion positive regulation of renal sodium excretion regulation of cell proliferation vasodilation positive regulation of nitric oxide biosynthetic process positive regulation of epidermal growth factor receptor signaling pathway positive regulation of blood pressure positive regulation of transcription, DNA-templated positive regulation of vasodilation fibroblast proliferation positive regulation of fibroblast proliferation regulation of long-term neuronal synaptic plasticity smooth muscle cell proliferation cytokine secretion positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity negative regulation of neurotrophin TRK receptor signaling pathway stress-activated MAPK cascade regulation of calcium ion transport regulation of transmission of nerve impulse cell growth involved in cardiac muscle cell development positive regulation of protein tyrosine kinase activity ERK1 and ERK2 cascade uterine smooth muscle contraction cellular response to mechanical stimulus positive regulation of branching involved in ureteric bud morphogenesis regulation of extracellular matrix assembly positive regulation of gap junction assembly regulation of cardiac conduction positive regulation of reactive oxygen species metabolic process positive regulation of extrinsic apoptotic signaling pathway
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