Recommended positive controls: 293T, A431, HeLa, HepG2, GL261, C8D30, NIH-3T3, Raw 264.7, PC-12, Rat2.
Predicted reactivity: Mouse (93%), Rat (91%), Dog (98%), Chimpanzee (100%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
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Protein Aliases: Anchorin CII; annexin 5; Annexin A5; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; epididymis secretory protein Li 7; Lipocortin V; PAP-I; Placental anticoagulant protein 4; Placental anticoagulant protein I; PP4; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha
Gene Aliases: ANX5; ANXA5; ENX2; HEL-S-7; LC5; PP4; R74653; RPRGL3
Molecular Function: calcium-binding protein