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Apelin Polyclonal Antibody
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FIGURE: 1 / 1
Apelin Antibody (600-401-R09) in WB
Western Blot of Rabbit Anti-Apelin antibody. Lane 1: U87 Cell Lysate. Lane 2: MCF-7 Cell Lysate. Lane 3: HELA Cell Lysate. Lane 4: MM453 Cell Lysate. Load: 35 µg per lane. Primary antibody: Apelin antibody at 1 µg/mL for overnight at 4°C. Secondary antibody: IRDye800 rabbit secondary antibody at 1:10,000 for 1.5 hr at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: ~9 kDa for Apelin. Other band(s): none.
Product Details
600-401-R09
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Apelin affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a sequence at the C-terminal of human Apelin.
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AGTRL1 ligand; Apelin; apelin, AGTRL1 ligand; APJ endogenous ligand; preproapelin; unnamed protein product
Gene Aliases: 6030430G11Rik; APEL; APLN; XNPEP2
UniProt ID: (Human) Q9ULZ1, (Mouse) Q9R0R4, (Rat) Q9R0R3
Entrez Gene ID: (Human) 8862, (Mouse) 30878, (Rat) 58812
regulation of the force of heart contraction
signal transduction
G-protein coupled receptor signaling pathway
feeding behavior
positive regulation of cell proliferation
positive regulation of heat generation
positive regulation of phosphorylation
drinking behavior
regulation of respiratory gaseous exchange
negative regulation of blood pressure
negative regulation of vasoconstriction
positive regulation of vasodilation
regulation of body fluid levels
positive regulation of corticotropin secretion
positive regulation of corticotropin-releasing hormone secretion
angiogenesis
G-protein coupled receptor internalization
negative regulation of systemic arterial blood pressure
immune response
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
gastrulation
lactation
positive regulation of heart rate
positive regulation of cardiac muscle hypertrophy
negative regulation of gene expression
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of heart contraction
apelin receptor signaling pathway
coronary vasculature development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of cardiac muscle hypertrophy in response to stress
positive regulation of cardiac muscle hypertrophy in response to stress
positive regulation of G protein-coupled receptor internalization
negative regulation of vascular smooth muscle cell proliferation
positive regulation of vascular endothelial cell proliferation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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