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Product Details
PA5-77862
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:3,000 | - |
Immunocytochemistry (ICC/IF) |
1:100-1:1,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Apolipoprotein CIII. The exact sequence is proprietary. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.34 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7, with 1% BSA, 20% glycerol |
Contains |
0.025% ProClin 300 |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2735459 |
Product Specific Information
Positive Control: human plasma
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apo-CIII; apoC-III; Apolipoprotein; Apolipoprotein C-III; Apolipoprotein C3; MGC150353
Gene Aliases: APOC3; APOCIII; HALP2
UniProt ID: (Human) P02656
Entrez Gene ID: (Human) 345
Molecular Function:
apolipoprotein
retinoid metabolic process
triglyceride metabolic process
inflammatory response
G-protein coupled receptor signaling pathway
positive regulation of triglyceride biosynthetic process
negative regulation of triglyceride catabolic process
negative regulation of very-low-density lipoprotein particle remodeling
negative regulation of very-low-density lipoprotein particle clearance
negative regulation of high-density lipoprotein particle clearance
negative regulation of low-density lipoprotein particle clearance
triglyceride catabolic process
regulation of Cdc42 protein signal transduction
response to vitamin A
cholesterol efflux
phospholipid efflux
response to triglyceride
high-density lipoprotein particle remodeling
very-low-density lipoprotein particle assembly
chylomicron remnant clearance
lipoprotein metabolic process
response to drug
cholesterol homeostasis
lipoprotein transport
response to peptide hormone
reverse cholesterol transport
negative regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
negative regulation of lipid catabolic process
negative regulation of lipoprotein lipase activity
negative regulation of cholesterol import
triglyceride homeostasis
response to fatty acid
cellular response to glucose stimulus
negative regulation of oxidative phosphorylation
response to simvastatin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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