Positive Control: human plasma
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Apolipoprotein CIII encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons. The encoded protein plays a role in role in the metabolism of these TRLs through multiple modes. This protein has been shown to promote the secretion of VLDL1, inhibit lipoprotein lipase enzyme activity, and delay catabolism of TRL remnants. Mutations in this gene are associated with low plasma triglyceride levels and reduced risk of ischemic cardiovascular disease, and hyperalphalipoproteinemia, which is characterized by elevated levels of high density lipoprotein (HDL) and HDL cholesterol in human patients. Apolipoprotein CIII and other related genes comprise an apolipoprotein gene cluster on chromosome 11.
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Protein Aliases: Apo-CIII; apoC-III; APOC3; APOCIII; Apolipoprotein C-III; Apolipoprotein C3; HALP2
Gene Aliases: APOC3; APOCIII; HALP2
UniProt ID: (Human) P02656
Entrez Gene ID: (Human) 345