Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: 293T, A431, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (99%), Rat (99%), Sheep (98%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site (PubMed:31204568). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658). [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADP-ribosylation factor-interacting protein 2; Arfaptin-2; Partner of RAC1; partner of RAC1 (arfaptin 2); POR1
Gene Aliases: ARFIP2; POR1
UniProt ID: (Human) P53365
Entrez Gene ID: (Human) 23647
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